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identification and SAR evaluation of hemozoin-inhibiting benzamides active against Plasmodium falciparum
Quinoline antimalarials target hemozoin formation causing a cytotoxic accumulation of ferriprotoporphyrin IX (Fe(III)PPIX). Well-developed SAR models exist for β-hematin inhibition, parasite activity and cellular mechanisms for this compound class, but no comparably detailed investigations exist for...
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| Publicado no: | J Med Chem |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4945415/ https://ncbi.nlm.nih.gov/pubmed/27299916 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b00719 |
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