Llwytho...

identification and SAR evaluation of hemozoin-inhibiting benzamides active against Plasmodium falciparum

Quinoline antimalarials target hemozoin formation causing a cytotoxic accumulation of ferriprotoporphyrin IX (Fe(III)PPIX). Well-developed SAR models exist for β-hematin inhibition, parasite activity and cellular mechanisms for this compound class, but no comparably detailed investigations exist for...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Med Chem
Prif Awduron: Wicht, Kathryn J., Combrinck, Jill M., Smith, Peter J., Hunter, Roger, Egan, Timothy J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4945415/
https://ncbi.nlm.nih.gov/pubmed/27299916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b00719
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