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Hemozoin inhibiting 2-phenylbenzimidazoles active against malaria parasites
The 2-phenylbenzimidazole scaffold has recently been discovered to inhibit β-hematin (synthetic hemozoin) formation by high throughput screening. Here, a library of 325,728 N-4-(1Hbenzo[d]imidazol-2-yl)aryl)benzamides was enumerated, and Bayesian statistics used to predict β-hematin and Plasmodium f...
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| Publicado no: | Eur J Med Chem |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6232849/ https://ncbi.nlm.nih.gov/pubmed/30296683 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2018.09.060 |
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