Hemozoin inhibiting 2-phenylbenzimidazoles active against malaria parasites

The 2-phenylbenzimidazole scaffold has recently been discovered to inhibit β-hematin (synthetic hemozoin) formation by high throughput screening. Here, a library of 325,728 N-4-(1Hbenzo[d]imidazol-2-yl)aryl)benzamides was enumerated, and Bayesian statistics used to predict β-hematin and Plasmodium f...

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Gepubliceerd in:Eur J Med Chem
Hoofdauteurs: L’abbate, Fabrizio P., Müller, Ronel, Openshaw, Roxanne, Combrinck, Jill M., de Villiers, Katherine A., Hunter, Roger, Egan, Timothy J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6232849/
https://ncbi.nlm.nih.gov/pubmed/30296683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2018.09.060
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