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Identification of β-hematin inhibitors in a high-throughput screening effort reveals scaffolds with in vitro antimalarial activity
The emergence of drug resistant strains of Plasmodium spp. creates a critical need for the development of novel antimalarials. Formation of hemozoin, a crystalline heme detoxification process vital to parasite survival serves as an important drug target. The quinoline antimalarials including chloroq...
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| Publicado no: | Int J Parasitol Drugs Drug Resist |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4266794/ https://ncbi.nlm.nih.gov/pubmed/25516843 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpddr.2014.08.002 |
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