Hematin Polymerization Assay as a High-Throughput Screen for Identification of New Antimalarial Pharmacophores

Hematin polymerization is a parasite-specific process that enables the detoxification of heme following its release in the lysosomal digestive vacuole during hemoglobin degradation, and represents both an essential and a unique pharmacological drug target. We have developed a high-throughput in vitr...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Kurosawa, Yae, Dorn, Arnulf, Kitsuji-Shirane, Michiko, Shimada, Hisao, Satoh, Tomoko, Matile, Hugues, Hofheinz, Werner, Masciadri, Raffaello, Kansy, Manfred, Ridley, Robert G.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2000
Assuntos:	Chemistry; Biosynthesis
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90128/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10991837/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.10.2638-2644.2000
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