Hematin Polymerization Assay as a High-Throughput Screen for Identification of New Antimalarial Pharmacophores

Hematin polymerization is a parasite-specific process that enables the detoxification of heme following its release in the lysosomal digestive vacuole during hemoglobin degradation, and represents both an essential and a unique pharmacological drug target. We have developed a high-throughput in vitr...

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Detalhes bibliográficos
Main Authors: Kurosawa, Yae, Dorn, Arnulf, Kitsuji-Shirane, Michiko, Shimada, Hisao, Satoh, Tomoko, Matile, Hugues, Hofheinz, Werner, Masciadri, Raffaello, Kansy, Manfred, Ridley, Robert G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2000
Assuntos:
Chemistry; Biosynthesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC90128/
https://ncbi.nlm.nih.gov/pubmed/10991837
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