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Enone- and chalcone-chloroquinoline hybrid analogs: In silico-guided design, synthesis, antiplasmodial activity, in vitro metabolism and mechanistic studies

Analogs of the previously reported antimalarial hybrid compounds 8b and 12 were proposed with the aim of identifying compounds with improved solubility and retained antimalarial potency. In silico characterization predicted improved solubilities of the analogs, particularly at low pH; they retained...

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Библиографические подробности
Главные авторы: Guantai, Eric M., Ncokazi, Kanyile, Egan, Timothy J., Gut, Jiri, Rosenthal, Philip J., Bhampidipati, Ravi, Kopinathan, Anitha, Smith, Peter J., Chibale, Kelly
Формат: Artigo
Язык:Inglês
Опубликовано: 2011
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3104272/
https://ncbi.nlm.nih.gov/pubmed/21500839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm200149e
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