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Functionalized Naphthalimide-4-aminoquinoline Conjugates as Promising Antiplasmodials, with Mechanistic Insights
[Image: see text] A series of 25 conjugates has been synthesized to evaluate their antiplasmodial potency and cytotoxicity against the chloroquine resistant (CQR) W2 strain of P. falciparum and Vero kidney cell lines, respectively. Most of the compounds showed IC(50) values in the lower nM range and...
Guardado en:
| Publicado en: | ACS Med Chem Lett |
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| Autores principales: | , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Chemical
Society
2020
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| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7025377/ https://ncbi.nlm.nih.gov/pubmed/32071682 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00521 |
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