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β-amino-alcohol tethered 4-aminoquinoline-isatin conjugates: Synthesis and antimalarial evaluation

A series of β-amino alcohol tethered 4-aminoquinoline-isatin conjugates were synthesized with the aim of probing their antimalarial structure activity relationship. Two of the most active conjugates (11b and 11f) exhibited antimalarial efficacy comparable to that of chloroquine, with IC(50) values o...

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Bibliografiske detaljer
Udgivet i:Eur J Med Chem
Main Authors: Nisha, Gut, Jiri, Rosenthal, Philip J., Kumar, Vipan
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier Masson SAS. 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7115587/
https://ncbi.nlm.nih.gov/pubmed/25062007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2014.07.064
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