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β-amino-alcohol tethered 4-aminoquinoline-isatin conjugates: Synthesis and antimalarial evaluation

A series of β-amino alcohol tethered 4-aminoquinoline-isatin conjugates were synthesized with the aim of probing their antimalarial structure activity relationship. Two of the most active conjugates (11b and 11f) exhibited antimalarial efficacy comparable to that of chloroquine, with IC(50) values o...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Eur J Med Chem
Egile Nagusiak: Nisha, Gut, Jiri, Rosenthal, Philip J., Kumar, Vipan
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Elsevier Masson SAS. 2014
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7115587/
https://ncbi.nlm.nih.gov/pubmed/25062007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2014.07.064
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