The use of mechanistic DM-PK-PD modelling to assess the power of pharmacogenetic studies –CYP2C9 and warfarin as an example

von Dickinson, Gemma L, Lennard, Martin S, Tucker, Geoffrey T, Rostami-Hodjegan, Amin
Veröffentlicht 2007

Quantitative Prediction of CYP3A4 and CYP3A5-Mediated Drug Interactions

von Guo, Yingying, Lucksiri, Aroonrut, Dickinson, Gemma L., Vuppalanchi, Raj K., Hilligoss, Janna K., Hall, Stephen D.
Veröffentlicht in Clin Pharmacol Ther (2019)

Predicting Clinical Effects of CYP3A4 Modulators on Abemaciclib and Active Metabolites Exposure Using Physiologically Based Pharmacokinetic Modeling

von Posada, Maria M., Morse, Bridget L., Turner, P. Kellie, Kulanthaivel, Palaniappan, Hall, Stephen D., Dickinson, Gemma L.
Veröffentlicht in J Clin Pharmacol (2020)

Physiologically‐Based Pharmacokinetic Modeling of Atorvastatin Incorporating Delayed Gastric Emptying and Acid‐to‐Lactone Conversion

von Morse, Bridget L., Alberts, Jeffrey J., Posada, Maria M., Rehmel, Jessica, Kolur, Anil, Tham, Lai San, Loghin, Corina, Hillgren, Kathleen M., Hall, Stephen D., Dickinson, Gemma L.
Veröffentlicht in CPT Pharmacometrics Syst Pharmacol (2019)

Receptor Occupancy of the κ-Opioid Antagonist LY2456302 Measured with Positron Emission Tomography and the Novel Radiotracer (11)C-LY2795050

von Naganawa, Mika, Dickinson, Gemma L., Zheng, Ming-Qiang, Henry, Shannan, Vandenhende, Francois, Witcher, Jennifer, Bell, Robert, Nabulsi, Nabeel, Lin, Shu-Fei, Ropchan, Jim, Neumeister, Alexander, Ranganathan, Mohini, Tauscher, Johannes, Huang, Yiyun, Carson, Richard E.
Veröffentlicht in J Pharmacol Exp Ther (2016)

Dose study of the multikinase inhibitor, LY2457546, in patients with relapsed acute myeloid leukemia to assess safety, pharmacokinetics, and pharmacodynamics

von Wacheck, Volker, Lahn, Michael, Dickinson, Gemma, Füreder, Wolfgang, Meyer, Renata, Herndlhofer, Susanne, Füreder, Thorsten, Dorfner, Georg, Pillay, Sada, André, Valérie, Burkholder, Timothy P, Akunda, Jacqueline K, Flye-Blakemore, Leann, Van Bockstaele, Dirk, Schlenk, Richard F, Sperr, Wolfgang R, Valent, Peter
Veröffentlicht 2011

Physiologically Based Pharmacokinetic Model Qualification and Reporting Procedures for Regulatory Submissions: A Consortium Perspective

von Shebley, Mohamad, Sandhu, Punam, Emami Riedmaier, Arian, Jamei, Masoud, Narayanan, Rangaraj, Patel, Aarti, Peters, Sheila Annie, Reddy, Venkatesh Pilla, Zheng, Ming, de Zwart, Loeckie, Beneton, Maud, Bouzom, Francois, Chen, Jun, Chen, Yuan, Cleary, Yumi, Collins, Christiane, Dickinson, Gemma L., Djebli, Nassim, Einolf, Heidi J., Gardner, Iain, Huth, Felix, Kazmi, Faraz, Khalil, Feras, Lin, Jing, Odinecs, Aleksandrs, Patel, Chirag, Rong, Haojing, Schuck, Edgar, Sharma, Pradeep, Wu, Shu‐Pei, Xu, Yang, Yamazaki, Shinji, Yoshida, Kenta, Rowland, Malcolm
Veröffentlicht in Clin Pharmacol Ther (2018)

A Quantitative Systems Pharmacology Consortium Approach to Managing Immunogenicity of Therapeutic Proteins

von Kierzek, Andrzej M., Hickling, Timothy P., Figueroa, Isabel, Kalvass, J. Cory, Nijsen, Marjoleen, Mohan, Krithika, Veldman, Geertruida M., Yamada, Akihiro, Sayama, Hiroyuki, Yokoo, Sachiko, Gulati, Abhishek, Dhanikula, Renu S., Gokemeijer, Jochem, Leil, Tarek A., Thalhauser, Craig J., Giorgi, Mario, Swat, Maciej J., Chelliah, Vijayalakshmi, Small, Ben G., Benson, Neil, Walker, Michael, Gadkar, Kapil, Quarmby, Valerie, Deng, Rong, Ferrante, Andrea, Dickinson, Gemma L., Van Der Walt, Jan‐Stefan, Zhou, Lian, Chen, Xiaoying, Jones, Hannah M., Narula, Jatin, Tourdot, Sophie, Lavé, Thierry, Ribba, Benjamin, van der Graaf, Piet H.
Veröffentlicht in CPT Pharmacometrics Syst Pharmacol (2019)