The use of mechanistic DM-PK-PD modelling to assess the power of pharmacogenetic studies –CYP2C9 and warfarin as an example

Por Dickinson, Gemma L, Lennard, Martin S, Tucker, Geoffrey T, Rostami-Hodjegan, Amin
Publicado em 2007

Quantitative Prediction of CYP3A4 and CYP3A5-Mediated Drug Interactions

Por Guo, Yingying, Lucksiri, Aroonrut, Dickinson, Gemma L., Vuppalanchi, Raj K., Hilligoss, Janna K., Hall, Stephen D.
Publicado no Clin Pharmacol Ther (2019)

Predicting Clinical Effects of CYP3A4 Modulators on Abemaciclib and Active Metabolites Exposure Using Physiologically Based Pharmacokinetic Modeling

Por Posada, Maria M., Morse, Bridget L., Turner, P. Kellie, Kulanthaivel, Palaniappan, Hall, Stephen D., Dickinson, Gemma L.
Publicado no J Clin Pharmacol (2020)

Physiologically‐Based Pharmacokinetic Modeling of Atorvastatin Incorporating Delayed Gastric Emptying and Acid‐to‐Lactone Conversion

Por Morse, Bridget L., Alberts, Jeffrey J., Posada, Maria M., Rehmel, Jessica, Kolur, Anil, Tham, Lai San, Loghin, Corina, Hillgren, Kathleen M., Hall, Stephen D., Dickinson, Gemma L.
Publicado no CPT Pharmacometrics Syst Pharmacol (2019)

Receptor Occupancy of the κ-Opioid Antagonist LY2456302 Measured with Positron Emission Tomography and the Novel Radiotracer (11)C-LY2795050

Por Naganawa, Mika, Dickinson, Gemma L., Zheng, Ming-Qiang, Henry, Shannan, Vandenhende, Francois, Witcher, Jennifer, Bell, Robert, Nabulsi, Nabeel, Lin, Shu-Fei, Ropchan, Jim, Neumeister, Alexander, Ranganathan, Mohini, Tauscher, Johannes, Huang, Yiyun, Carson, Richard E.
Publicado no J Pharmacol Exp Ther (2016)

Dose study of the multikinase inhibitor, LY2457546, in patients with relapsed acute myeloid leukemia to assess safety, pharmacokinetics, and pharmacodynamics

Por Wacheck, Volker, Lahn, Michael, Dickinson, Gemma, Füreder, Wolfgang, Meyer, Renata, Herndlhofer, Susanne, Füreder, Thorsten, Dorfner, Georg, Pillay, Sada, André, Valérie, Burkholder, Timothy P, Akunda, Jacqueline K, Flye-Blakemore, Leann, Van Bockstaele, Dirk, Schlenk, Richard F, Sperr, Wolfgang R, Valent, Peter
Publicado em 2011

Physiologically Based Pharmacokinetic Model Qualification and Reporting Procedures for Regulatory Submissions: A Consortium Perspective

Por Shebley, Mohamad, Sandhu, Punam, Emami Riedmaier, Arian, Jamei, Masoud, Narayanan, Rangaraj, Patel, Aarti, Peters, Sheila Annie, Reddy, Venkatesh Pilla, Zheng, Ming, de Zwart, Loeckie, Beneton, Maud, Bouzom, Francois, Chen, Jun, Chen, Yuan, Cleary, Yumi, Collins, Christiane, Dickinson, Gemma L., Djebli, Nassim, Einolf, Heidi J., Gardner, Iain, Huth, Felix, Kazmi, Faraz, Khalil, Feras, Lin, Jing, Odinecs, Aleksandrs, Patel, Chirag, Rong, Haojing, Schuck, Edgar, Sharma, Pradeep, Wu, Shu‐Pei, Xu, Yang, Yamazaki, Shinji, Yoshida, Kenta, Rowland, Malcolm
Publicado no Clin Pharmacol Ther (2018)

A Quantitative Systems Pharmacology Consortium Approach to Managing Immunogenicity of Therapeutic Proteins

Por Kierzek, Andrzej M., Hickling, Timothy P., Figueroa, Isabel, Kalvass, J. Cory, Nijsen, Marjoleen, Mohan, Krithika, Veldman, Geertruida M., Yamada, Akihiro, Sayama, Hiroyuki, Yokoo, Sachiko, Gulati, Abhishek, Dhanikula, Renu S., Gokemeijer, Jochem, Leil, Tarek A., Thalhauser, Craig J., Giorgi, Mario, Swat, Maciej J., Chelliah, Vijayalakshmi, Small, Ben G., Benson, Neil, Walker, Michael, Gadkar, Kapil, Quarmby, Valerie, Deng, Rong, Ferrante, Andrea, Dickinson, Gemma L., Van Der Walt, Jan‐Stefan, Zhou, Lian, Chen, Xiaoying, Jones, Hannah M., Narula, Jatin, Tourdot, Sophie, Lavé, Thierry, Ribba, Benjamin, van der Graaf, Piet H.
Publicado no CPT Pharmacometrics Syst Pharmacol (2019)