Physiologically‐Based Pharmacokinetic Modeling of Atorvastatin Incorporating Delayed Gastric Emptying and Acid‐to‐Lactone Conversion

The drug–drug interaction profile of atorvastatin confirms that disposition is determined by cytochrome P450 (CYP) 3A4 and organic anion transporting polypeptides (OATPs). Drugs that affect gastric emptying, including dulaglutide, also affect atorvastatin pharmacokinetics (PK). Atorvastatin is a car...

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Detalhes bibliográficos
Publicado no:CPT Pharmacometrics Syst Pharmacol
Main Authors: Morse, Bridget L., Alberts, Jeffrey J., Posada, Maria M., Rehmel, Jessica, Kolur, Anil, Tham, Lai San, Loghin, Corina, Hillgren, Kathleen M., Hall, Stephen D., Dickinson, Gemma L.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6765700/
https://ncbi.nlm.nih.gov/pubmed/31250974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12447
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