Paraoxonase (PON1 and PON3) Polymorphisms: Impact on Liver Expression and Atorvastatin-Lactone Hydrolysis

Atorvastatin δ-lactone, a major, pharmacologically inactive metabolite, has been associated with toxicity. In a previous study we showed that polymorphisms of UGT1A3 influence atorvastatin δ-lactone formation. Here we investigated the reverse reaction, atorvastatin δ-lactone hydrolysis, in a human l...

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Autori principali: Riedmaier, Stephan, Klein, Kathrin, Winter, Stefan, Hofmann, Ute, Schwab, Matthias, Zanger, Ulrich M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Research Foundation 2011
Soggetti:
Pharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3147178/
https://ncbi.nlm.nih.gov/pubmed/21852972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2011.00041
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