Pathway-Targeted Pharmacogenomics of CYP1A2 in Human Liver

The human drug metabolizing cytochrome P450 (CYP) 1A2, is one of the major P450 isoforms contributing by about 5–20% to the hepatic P450 pool and catalyzing oxidative biotransformation of up to 10% of clinically relevant drugs including clozapine and caffeine. CYP1A2 activity is interindividually hi...

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Autors principals: Klein, Kathrin, Winter, Stefan, Turpeinen, Miia, Schwab, Matthias, Zanger, Ulrich M.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Research Foundation 2010
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3171976/
https://ncbi.nlm.nih.gov/pubmed/21918647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2010.00129
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