Effect of Genetic Variability in the CYP4F2, CYP4F11, and CYP4F12 Genes on Liver mRNA Levels and Warfarin Response

Genetic polymorphisms in the gene encoding cytochrome P450 (CYP) 4F2, a vitamin K oxidase, affect stable warfarin dose requirements and time to therapeutic INR. CYP4F2 is part of the CYP4F gene cluster, which is highly polymorphic and exhibits a high degree of linkage disequilibrium, making it diffi...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Zhang, J. E., Klein, Kathrin, Jorgensen, Andrea L., Francis, Ben, Alfirevic, Ana, Bourgeois, Stephane, Deloukas, Panagiotis, Zanger, Ulrich M., Pirmohamed, Munir
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5449482/
https://ncbi.nlm.nih.gov/pubmed/28620303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00323
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