A Genome-Wide Association Study Confirms VKORC1, CYP2C9, and CYP4F2 as Principal Genetic Determinants of Warfarin Dose

We report the first genome-wide association study (GWAS) whose sample size (1,053 Swedish subjects) is sufficiently powered to detect genome-wide significance (p<1.5×10(−7)) for polymorphisms that modestly alter therapeutic warfarin dose. The anticoagulant drug warfarin is widely prescribed for r...

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Detalhes bibliográficos
Main Authors: Takeuchi, Fumihiko, McGinnis, Ralph, Bourgeois, Stephane, Barnes, Chris, Eriksson, Niclas, Soranzo, Nicole, Whittaker, Pamela, Ranganath, Venkatesh, Kumanduri, Vasudev, McLaren, William, Holm, Lennart, Lindh, Jonatan, Rane, Anders, Wadelius, Mia, Deloukas, Panos
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2652833/
https://ncbi.nlm.nih.gov/pubmed/19300499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000433
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