The largest prospective warfarin-treated cohort supports genetic forecasting

Genetic variants of cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase (VKORC1) are known to influence warfarin dose, but the effect of other genes has not been fully elucidated. We genotyped 183 polymorphisms in 29 candidate genes in 1496 Swedish patients starting warfarin treatment, and...

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Hauptverfasser: Wadelius, Mia, Chen, Leslie Y., Lindh, Jonatan D., Eriksson, Niclas, Ghori, Mohammed J. R., Bumpstead, Suzannah, Holm, Lennart, McGinnis, Ralph, Rane, Anders, Deloukas, Panos
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2009
Schlagworte:
Clinical Trials and Observations
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2630264/
https://ncbi.nlm.nih.gov/pubmed/18574025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-04-149070
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