The largest prospective warfarin-treated cohort supports genetic forecasting

Genetic variants of cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase (VKORC1) are known to influence warfarin dose, but the effect of other genes has not been fully elucidated. We genotyped 183 polymorphisms in 29 candidate genes in 1496 Swedish patients starting warfarin treatment, and...

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Autori principali: Wadelius, Mia, Chen, Leslie Y., Lindh, Jonatan D., Eriksson, Niclas, Ghori, Mohammed J. R., Bumpstead, Suzannah, Holm, Lennart, McGinnis, Ralph, Rane, Anders, Deloukas, Panos
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2009
Soggetti:
Clinical Trials and Observations
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2630264/
https://ncbi.nlm.nih.gov/pubmed/18574025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-04-149070
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