Of Mice and Men-Warning: Intact Versus Castrated Adult Male Mice as Xenograft Hosts Are Equivalent to Hypogonadal Versus Abiraterone Treated Aging Human Males, Respectively

Por Sedelaar, J.P. Michiel, Dalrymple, Susan S., Isaacs, John T.
Publicado em 2013

Androgen Receptor (AR) Suppresses Normal Human Prostate Epithelial Cell Proliferation via AR/β-catenin/TCF-4 Complex Inhibition of c-MYC Transcription

Por Antony, Lizamma, van der Schoor, Freek, Dalrymple, Susan L., Isaacs, John T.
Publicado no Prostate (2014)

Tasquinimod Prevents the Angiogenic Rebound Induced by Fractionated Radiation Resulting in an Enhanced Therapeutic Response of Prostate Cancer Xenografts

Por Dalrymple, Susan L., Becker, Robyn E., Zhou, Haoming, DeWeese, Theodore L., Isaacs, John T.
Publicado em 2011

Anti-cancer potency of tasquinimod is enhanced via albumin-binding facilitating increased uptake in the tumor microenvironment

Por Isaacs, John T., Dalrymple, Susan L., Rosen, D. Marc, Hammers, Hans, Olsson, Anders, Leanderson, Tomas
Publicado no Oncotarget (2014)

Low-Calcium Serum-Free Defined Medium Selects for Growth of Normal Prostatic Epithelial Stem Cells

Por Litvinov, Ivan V., Vander Griend, Donald J., Xu, Yi, Antony, Lizamma, Dalrymple, Susan L., Isaacs, John T.
Publicado em 2006

The Role of CD133 in Normal Human Prostate Stem Cells and Malignant Cancer-Initiating Cells

Por Vander Griend, Donald J., Karthaus, Wouter L., Dalrymple, Susan, Meeker, Alan, DeMarzo, Angelo M., Isaacs, John T.
Publicado em 2008

Assessing angiogenic responses induced by primary human prostate stromal cells in a three-dimensional fibrin matrix assay

Por Brennen, W. Nathaniel, Nguyen, Huong, Dalrymple, Susan L., Reppert-Gerber, Stephanie, Kim, Jeesun, Isaacs, John T., Hammers, Hans
Publicado no Oncotarget (2016)

Amino acid containing thapsigargin analogues deplete androgen receptor protein via synthesis inhibition and induce the death of prostate cancer cells

Por Vander Griend, Donald J., Antony, Lizamma, Dalrymple, Susan L., Xu, Yi, Christensen, S. Brogger, Denmeade, Samuel R., Isaacs, John T.
Publicado em 2009

Loss of Androgen Receptor-Dependent Growth Suppression by Prostate Cancer Cells Can Occur Independently from Acquiring Oncogenic Addiction to Androgen Receptor Signaling

Por D'Antonio, Jason M., Vander Griend, Donald J., Antony, Lizamma, Ndikuyeze, George, Dalrymple, Susan L., Koochekpour, Shahriar, Isaacs, John T.
Publicado em 2010

Androgen Withdrawal Fails to Induce Detectable Tissue Hypoxia in the Rat Prostate

Por Regter, Sietze, Hedayati, Mohammad, Zhang, Yonggang, Zhou, Haoming, Dalrymple, Susan, Koch, Cameron J., Isaacs, John T., DeWeese, Theodore L.
Publicado no Prostate (2014)

Androgen receptor as a licensing factor for DNA replication in androgen-sensitive prostate cancer cells

Por Litvinov, Ivan V., Vander Griend, Donald J., Antony, Lizamma, Dalrymple, Susan, De Marzo, Angelo M., Drake, Charles G., Isaacs, John T.
Publicado em 2006

Adaptive Auto-Regulation of Androgen Receptor Provides a Paradigm Shifting Rationale for Bipolar Androgen Therapy (BAT) for Castrate Resistant Human Prostate Cancer

Por Isaacs, John T., D’Antonio, Jason M., Chen, Shuangling, Antony, Lizamma, Dalrymple, Susan P., Ndikuyeze, Georges H., Luo, Jun, Denmeade, Samuel R.
Publicado em 2012

Tasquinimod is an Allosteric Modulator of HDAC4 Survival Signaling within the Compromised Cancer Microenvironment

Por Isaacs, John T, Antony, Lizamma, Dalrymple, Susan L, Brennen, W. Nathaniel, Gerber, Stephanie, Hammers, Hans, Wissing, Michel, Kachhap, Sushant, Luo, Jun, Xing, Li, Björk, Per, Olsson, Anders, Björk, Anders, Leanderson, Tomas
Publicado em 2012

Androgen deprivation followed by acute androgen stimulation selectively sensitizes AR-positive prostate cancer cells to ionizing radiation

Por Hedayati, Mohammad, Haffner, Michael C., Coulter, Jonathan B., Raval, Raju R., Zhang, Yonggang, Zhou, Haoming, Mian, Omar, Knight, Emma J., Razavi, Nina, Dalrymple, Susan, Isaacs, John T., Santos, Aileen, Hales, Russell, Nelson, William G., Yegnasubramanian, Srinivasan, DeWeese, Theodore L.
Publicado no Clin Cancer Res (2016)

Engineering a Prostate-Specific Membrane Antigen–Activated Tumor Endothelial Cell Prodrug for Cancer Therapy

Por Denmeade, Samuel R., Mhaka, Annastasiah M., Rosen, D. Marc, Brennen, W. Nathaniel, Dalrymple, Susan, Dach, Ingrid, Olesen, Claus, Gurel, Bora, DeMarzo, Angelo M., Wilding, George, Carducci, Michael A., Dionne, Craig A., Møller, Jesper V., Nissen, Poul, Christensen, S. Brøgger, Isaacs, John T.
Publicado em 2012