Amino acid containing thapsigargin analogues deplete androgen receptor protein via synthesis inhibition and induce the death of prostate cancer cells

There are quantitative and/or qualitative mechanisms allowing androgen receptor (AR) growth signaling in androgen ablation refractory prostate cancer cells. Regardless of the mechanism, agents that deplete AR protein expression prevent such AR growth signaling. Thapsigargin (TG) is a highly cell-pen...

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Bibliographic Details
Main Authors: Vander Griend, Donald J., Antony, Lizamma, Dalrymple, Susan L., Xu, Yi, Christensen, S. Brogger, Denmeade, Samuel R., Isaacs, John T.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3383025/
https://ncbi.nlm.nih.gov/pubmed/19417145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-08-1136
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