Androgen deprivation followed by acute androgen stimulation selectively sensitizes AR-positive prostate cancer cells to ionizing radiation

PURPOSE: The current standard of care for patients with locally advanced prostate cancer is a combination of androgen deprivation and radiation therapy. Radiation is typically given with androgen suppression when testosterone levels are at their nadir. Recent reports have shown that androgen stimula...

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Gepubliceerd in:Clin Cancer Res
Hoofdauteurs: Hedayati, Mohammad, Haffner, Michael C., Coulter, Jonathan B., Raval, Raju R., Zhang, Yonggang, Zhou, Haoming, Mian, Omar, Knight, Emma J., Razavi, Nina, Dalrymple, Susan, Isaacs, John T., Santos, Aileen, Hales, Russell, Nelson, William G., Yegnasubramanian, Srinivasan, DeWeese, Theodore L.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4930695/
https://ncbi.nlm.nih.gov/pubmed/26831716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-1147
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