Androgen Receptor (AR) Suppresses Normal Human Prostate Epithelial Cell Proliferation via AR/β-catenin/TCF-4 Complex Inhibition of c-MYC Transcription

INTRODUCTION: Physiologic testosterone continuously stimulates prostate stromal cell secretion of paracrine growth factors (PGFs), which if unopposed would induce hyperplastic overgrowth of normal prostate epithelial cells (PrECs). METHODS: Lentiviral shRNA stable knock down of c-MYC, β-catenin, or...

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Publicado en:Prostate
Autores principales: Antony, Lizamma, van der Schoor, Freek, Dalrymple, Susan L., Isaacs, John T.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4856018/
https://ncbi.nlm.nih.gov/pubmed/24913829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pros.22828
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