Engineering a Prostate-Specific Membrane Antigen–Activated Tumor Endothelial Cell Prodrug for Cancer Therapy

Heterogeneous expression of drug target proteins within tumor sites is a major mechanism of resistance to anticancer therapies. We describe a strategy to selectively inhibit, within tumor sites, the function of a critical intracellular protein, the sarcoplasmic/endoplasmic reticulum calcium adenosin...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Denmeade, Samuel R., Mhaka, Annastasiah M., Rosen, D. Marc, Brennen, W. Nathaniel, Dalrymple, Susan, Dach, Ingrid, Olesen, Claus, Gurel, Bora, DeMarzo, Angelo M., Wilding, George, Carducci, Michael A., Dionne, Craig A., Møller, Jesper V., Nissen, Poul, Christensen, S. Brøgger, Isaacs, John T.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2012
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3715055/
https://ncbi.nlm.nih.gov/pubmed/22745436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3003886
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