Pharmacokinetics and Toxicology of a Fibroblast Activation Protein (FAP)-activated Prodrug in Murine Xenograft Models of Human Cancer

BACKGROUND: As carcinoma progresses, the stroma undergoes a variety of phenotypic changes, including the presence of carcinoma-associated fibroblasts (CAFs) that express fibroblast activation protein (FAP). FAP is a post-prolyl endopeptidase whose expression in a healthy adult is largely restricted...

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Hauptverfasser: Brennen, W. Nathaniel, Rosen, D. Marc, Chaux, Alcides, Netto, George J., Isaacs, John T., Denmeade, Samuel R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4130904/
https://ncbi.nlm.nih.gov/pubmed/25053236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pros.22847
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