Overcoming stromal barriers to immuno-oncological responses via fibroblast activation protein-targeted therapy

The tumor microenvironment contributes to disease progression through multiple mechanisms, including immune suppression mediated in part by fibroblast activation protein (FAP)-expressing cells. Herein, a review of FAP biology is presented, supplemented with primary data. This includes FAP expression...

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Publicat a:Immunotherapy
Autors principals: Brennen, W Nathaniel, J Thorek, Daniel L, Jiang, Wen, Krueger, Timothy E, Antony, Lizamma, Denmeade, Samuel R, Isaacs, John T
Format: Artigo
Idioma:Inglês
Publicat: Future Medicine Ltd 2020
Matèries:
Special Report
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8008208/
https://ncbi.nlm.nih.gov/pubmed/33148078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/imt-2020-0066
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