Big data: the next frontier for innovation in therapeutics and healthcare

Por Issa, Naiem T, Byers, Stephen W, Dakshanamurthy, Sivanesan
Publicado no Expert Rev Clin Pharmacol (2014)

Retinoic Acid Mediates Regulation of Network Formation by COUP-TFII and VE-Cadherin Expression by TGFβ Receptor Kinase in Breast Cancer Cells

Por Prahalad, Priya, Dakshanamurthy, Sivanesan, Ressom, Habtom, Byers, Stephen W.
Publicado em 2010

Drug repurposing a reality: from computers to the clinic

Por Issa, Naiem T, Kruger, Jordan, Byers, Stephen W, Dakshanamurthy, Sivanesan
Publicado no Expert Rev Clin Pharmacol (2013)

Allelic Variation of Killer Cell Immunoglobulin-Like Receptor 2DS5 Impacts Glycosylation Altering Cell Surface Expression Levels

Por Steiner, Noriko K., Dakshanamurthy, Sivanesan, Nguyen, Nicholas, Hurley, Carolyn K.
Publicado em 2013

Allelic Variation in KIR2DL3 Generates a KIR2DL2-like Receptor with Increased Binding to Its HLA-C Ligand()

Por Frazier, William R., Steiner, Noriko, Hou, Lihua, Dakshanamurthy, Sivanesan, Hurley, Carolyn Katovich
Publicado em 2013

Accelerating Virtual High-Throughput Ligand Docking: current technology and case study on a petascale supercomputer

Por Ellingson, Sally R., Dakshanamurthy, Sivanesan, Brown, Milton, Smith, Jeremy C., Baudry, Jerome
Publicado em 2013

Tyrosine-phosphorylated Caveolin-1 (Tyr-14) Increases Sensitivity to Paclitaxel by Inhibiting BCL2 and BCLxL Proteins via c-Jun N-terminal Kinase (JNK)

Por Shajahan, Ayesha N., Dobbin, Zachary C., Hickman, F. Edward, Dakshanamurthy, Sivanesan, Clarke, Robert
Publicado em 2012

DrugGenEx-Net: a novel computational platform for systems pharmacology and gene expression-based drug repurposing

Por Issa, Naiem T., Kruger, Jordan, Wathieu, Henri, Raja, Rajarajan, Byers, Stephen W., Dakshanamurthy, Sivanesan
Publicado no BMC Bioinformatics (2016)

Dramatically reduced surface expression of NK cell receptor KIR2DS3 is attributed to multiple residues throughout the molecule

Por VandenBussche, Christopher James, Mulrooney, Tiernan Joseph, Frazier, William Robinson, Dakshanamurthy, Sivanesan, Hurley, Carolyn Katovich
Publicado em 2008

Cancer Preventive Isothiocyanates Induce Selective Degradation of Cellular α- and β-Tubulins by Proteasomes

Por Mi, Lixin, Gan, Nanqin, Cheema, Amrita, Dakshanamurthy, Sivanesan, Wang, Xiantao, Yang, David C. H., Chung, Fung-Lung
Publicado em 2009

Polygamain, a New Microtubule Depolymerizing Agent That Occupies a Unique Pharmacophore in the Colchicine Site

Por Hartley, R. M., Peng, J., Fest, G. A., Dakshanamurthy, S., Frantz, D. E., Brown, M. L., Mooberry, S. L.
Publicado em 2012

Asymmetric Synthesis of 2,3-Dihydro-2-arylquinazolin-4-ones: Methodology and Application to a Potent Fluorescent Tubulin Inhibitor with Anticancer Activity

Por Chinigo, Gary M., Paige, Mikell, Grindrod, Scott, Hamel, Ernest, Dakshanamurthy, Sivanesan, Chruszcz, Maksymilian, Minor, Wladek, Brown, Milton L.
Publicado em 2008

Tumor suppressor RARRES1 interacts with cytoplasmic carboxypeptidase AGBL2 to regulate the α-tubulin tyrosination cycle

Por Sahab, Ziad J., Hall, Michael D., Sung, You Me, Dakshanamurthy, Sivanesan, Ji, Yun, Kumar, Deepak, Byers, Stephen W.
Publicado em 2011

Evaluating the potential impact of mismatches outside the antigen recognition site in unrelated hematopoietic stem cell transplantation: HLA-DRB1*1454 and DRB1*140101

Por Xiao, Y., Lazaro, A. M., Masaberg, C., Haagenson, M., Vierra-Green, C., Spellman, S., Dakshanamurthy, S., Ng, J., Hurley, C. K.
Publicado em 2009

Predicting New Indications for Approved Drugs Using a Proteo-Chemometric Method

Por Dakshanamurthy, Sivanesan, Issa, Naiem T, Assefnia, Shahin, Seshasayee, Ashwini, Peters, Oakland J, Madhavan, Subha, Uren, Aykut, Brown, Milton L, Byers, Stephen W
Publicado em 2012

Covalent Binding to Tubulin by Isothiocyanates: A MECHANISM OF CELL GROWTH ARREST AND APOPTOSIS

Por Mi, Lixin, Xiao, Zhen, Hood, Brian L., Dakshanamurthy, Sivanesan, Wang, Xiantao, Govind, Sudha, Conrads, Thomas P., Veenstra, Timothy D., Chung, Fung-Lung
Publicado em 2008

Naturally occurring polyphenol, morin hydrate, inhibits enzymatic activity of N-methylpurine DNA glycosylase, a DNA repair enzyme with various roles in human disease

Por Dixon, Monica, Woodrick, Jordan, Gupta, Suhani, Karmahapatra, Soumendra Krishna, Devito, Stephen, Vasudevan, Sona, Dakshanamurthy, Sivanesan, Adhikari, Sanjay, Yenugonda, Venkata M., Roy, Rabindra
Publicado no Bioorg Med Chem (2015)

Tyrosine Phosphorylation of the Nuclear Receptor Coactivator AIB1/SRC-3 Is Enhanced by Abl Kinase and Is Required for Its Activity in Cancer Cells

Por Oh, Annabell S., Lahusen, John T., Chien, Christopher D., Fereshteh, Mark P., Zhang, Xiaolong, Dakshanamurthy, Sivanesan, Xu, Jianming, Kagan, Benjamin L., Wellstein, Anton, Riegel, Anna T.
Publicado em 2008

Differential prioritization of therapies to subtypes of triple negative breast cancer using a systems medicine method

Por Wathieu, Henri, Issa, Naiem T., Fernandez, Aileen I., Mohandoss, Manisha, Tiek, Deanna M., Franke, Jennifer L., Byers, Stephen W., Riggins, Rebecca B., Dakshanamurthy, Sivanesan
Publicado no Oncotarget (2017)

Inhibition of cell proliferation by a resveratrol analog in human pancreatic and breast cancer cells

Por Hong, Young Bin, Kang, Hyo Jin, Kim, Hee Jeong, Rosen, Eliot M., Dakshanamurthy, Sivanesan, Rondanin, Riccardo, Baruchello, Riccardo, Grisolia, Giuseppina, Daniele, Simoni, Bae, Insoo
Publicado em 2009