Bromodomains: Are Readers Right for Epigenetic Therapy?

Por Conway, Stuart J.
Publicado em 2012

The photochemical thiol–ene reaction as a versatile method for the synthesis of glutathione S-conjugates targeting the bacterial potassium efflux system Kef

Por Healy, Jess, Rasmussen, Tim, Miller, Samantha, Booth, Ian R., Conway, Stuart J.
Publicado no Org Chem Front (2016)

Pyocyanin degradation by a tautomerizing demethylase inhibits Pseudomonas aeruginosa biofilms

Por Costa, Kyle C, Glasser, Nathaniel R, Conway, Stuart J, Newman, Dianne K
Publicado no Science (2016)

KefF, the Regulatory Subunit of the Potassium Efflux System KefC, Shows Quinone Oxidoreductase Activity

Por Lyngberg, Lisbeth, Healy, Jessica, Bartlett, Wendy, Miller, Samantha, Conway, Stuart J., Booth, Ian R., Rasmussen, Tim
Publicado em 2011

Distinct Intracellular Calcium Transients in Neurites and Somata Integrate Neuronal Signals

Por Johenning, Friedrich W., Zochowski, Michal, Conway, Stuart J., Holmes, Andrew B., Koulen, Peter, Ehrlich, Barbara E.
Publicado no J Neurosci (2002)

Co-incident signalling between mu-opioid and M3 muscarinic receptors at the level of Ca2+ release from intracellular stores: lack of evidence for Ins(1,4,5)P3 receptor sensitizatio...

Por Samways, Damien S K, Li, Wen-hong, Conway, Stuart J, Holmes, Andrew B, Bootman, Martin D, Henderson, Graeme
Publicado em 2003

Production and characterization of reduced NAADP (nicotinic acid-adenine dinucleotide phosphate).

Por Billington, Richard A, Thuring, Jan W, Conway, Stuart J, Packman, Len, Holmes, Andrew B, Genazzani, Armando A
Publicado em 2004

Phenylglycine derivatives as antagonists of group III metabotropic glutamate receptors expressed on neonatal rat primary afferent terminals

Por Miller, Jacqueline C, Howson, Patrick A, Conway, Stuart J, Williams, Richard V, Clark, Barry P, Jane, David E
Publicado em 2003

Increased InsP(3)Rs in the junctional sarcoplasmic reticulum augment Ca(2+) transients and arrhythmias associated with cardiac hypertrophy

Por Harzheim, Dagmar, Movassagh, Mehregan, Foo, Roger S.-Y., Ritter, Oliver, Tashfeen, Aslam, Conway, Stuart J., Bootman, Martin D., Roderick, H. Llewelyn
Publicado em 2009

Mechanism of ligand-gated potassium efflux in bacterial pathogens

Por Roosild, Tarmo P., Castronovo, Samantha, Healy, Jess, Miller, Samantha, Pliotas, Christos, Rasmussen, Tim, Bartlett, Wendy, Conway, Stuart J., Booth, Ian R.
Publicado em 2010

CYP450 Enzymes Effect Oxygen-Dependent Reduction of Azide-Based Fluorogenic Dyes

Por O’Connor, Liam J., Mistry, Ishna N., Collins, Sarah L., Folkes, Lisa K., Brown, Graham, Conway, Stuart J., Hammond, Ester M.
Publicado no ACS Cent Sci (2016)

Interaction of the mechanosensitive channel, MscS, with the membrane bilayer through lipid intercalation into grooves and pockets.

Por Rasmussen, Tim, Rasmussen, Akiko, Yang, Limin, Kaul, Corinna, Black, Susan, Galbiati, Heloisa, Conway, Stuart J., Miller, Samantha, Blount, Paul, Booth, Ian Rylance
Publicado no J Mol Biol (2019)

Engineering transkingdom signalling in plants to control gene expression in rhizosphere bacteria

Por Geddes, Barney A., Paramasivan, Ponraj, Joffrin, Amelie, Thompson, Amber L., Christensen, Kirsten, Jorrin, Beatriz, Brett, Paul, Conway, Stuart J., Oldroyd, Giles E. D., Poole, Philip S.
Publicado no Nat Commun (2019)

3,5-Dimethylisoxazoles Act As Acetyl-lysine-mimetic Bromodomain Ligands

Por Hewings, David S., Wang, Minghua, Philpott, Martin, Fedorov, Oleg, Uttarkar, Sagar, Filippakopoulos, Panagis, Picaud, Sarah, Vuppusetty, Chaitanya, Marsden, Brian, Knapp, Stefan, Conway, Stuart J., Heightman, Tom D.
Publicado em 2011

Understanding the Structural Requirements for Activators of the Kef Bacterial Potassium Efflux System

Por Healy, Jessica, Ekkerman, Silvia, Pliotas, Christos, Richard, Morgiane, Bartlett, Wendy, Grayer, Samuel C., Morris, Garrett M., Miller, Samantha, Booth, Ian R., Conway, Stuart J., Rasmussen, Tim
Publicado em 2014

CH-01 is a Hypoxia-Activated Prodrug That Sensitizes Cells to Hypoxia/Reoxygenation Through Inhibition of Chk1 and Aurora A

Por Cazares-Körner, Cindy, Pires, Isabel M., Swallow, I. Diane, Grayer, Samuel C., O’Connor, Liam J., Olcina, Monica M., Christlieb, Martin, Conway, Stuart J., Hammond, Ester M.
Publicado em 2013

The design and synthesis of 5- and 6-isoxazolylbenzimidazoles as selective inhibitors of the BET bromodomains

Por Hay, Duncan, Fedorov, Oleg, Filippakopoulos, Panagis, Martin, Sarah, Philpott, Martin, Picaud, Sarah, Hewings, David S., Uttakar, Sagar, Heightman, Tom D., Conway, Stuart J., Knapp, Stefan, Brennan, Paul E.
Publicado no Medchemcomm (2013)

High-density functional-RNA arrays as a versatile platform for studying RNA-based interactions

Por Phillips, Jack O, Butt, Louise E, Henderson, Charlotte A, Devonshire, Martin, Healy, Jess, Conway, Stuart J, Locker, Nicolas, Pickford, Andrew R, Vincent, Helen A, Callaghan, Anastasia J
Publicado no Nucleic Acids Res (2018)

Pharmacological Inhibition of ATR Can Block Autophagy through an ATR-Independent Mechanism

Por Bowler, Elizabeth, Skwarska, Anna, Wilson, Joseph D., Ramachandran, Shaliny, Bolland, Hannah, Easton, Alistair, Ostheimer, Christian, Hwang, Ming-Shih, Leszczynska, Katarzyna B., Conway, Stuart J., Hammond, Ester M.
Publicado no iScience (2020)

Isoxazole‐Derived Amino Acids are Bromodomain‐Binding Acetyl‐Lysine Mimics: Incorporation into Histone H4 Peptides and Histone H3

Por Sekirnik (née Measures), Angelina R., Hewings, David S., Theodoulou, Natalie H., Jursins, Lukass, Lewendon, Katie R., Jennings, Laura E., Rooney, Timothy P. C., Heightman, Tom D., Conway, Stuart J.
Publicado no Angew Chem Int Ed Engl (2016)