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The photochemical thiol–ene reaction as a versatile method for the synthesis of glutathione S-conjugates targeting the bacterial potassium efflux system Kef

The thiol–ene coupling reaction is emerging as an important conjugation reaction that is suitable for use in a biological setting. Here, we explore the utility of this reaction for the synthesis of glutathione-S-conjugates (GSX) and present a general, operationally simple, protocol with a wide subst...

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Bibliographic Details
Published in:Org Chem Front
Main Authors: Healy, Jess, Rasmussen, Tim, Miller, Samantha, Booth, Ian R., Conway, Stuart J.
Format: Artigo
Language:Inglês
Published: Royal Society of Chemistry 2016
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4819703/
https://ncbi.nlm.nih.gov/pubmed/27110363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5qo00436e
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