Pharmacological Inhibition of ATR Can Block Autophagy through an ATR-Independent Mechanism

Inhibition of the ATR kinase has emerged as a therapeutically attractive means to target cancer since the development of potent inhibitors, which are now in clinical testing. We investigated a potential link between ATR inhibition and the autophagy process in esophageal cancer cells using four ATR i...

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Detalhes bibliográficos
Publicado no:iScience
Main Authors: Bowler, Elizabeth, Skwarska, Anna, Wilson, Joseph D., Ramachandran, Shaliny, Bolland, Hannah, Easton, Alistair, Ostheimer, Christian, Hwang, Ming-Shih, Leszczynska, Katarzyna B., Conway, Stuart J., Hammond, Ester M.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7588853/
https://ncbi.nlm.nih.gov/pubmed/33134898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101668
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