Preclinical testing of an Atr inhibitor demonstrates improved response to standard therapies for esophageal cancer

BACKGROUND AND PURPOSE: Esophageal cancer has a persistently low 5-year survival rate and has recently been classified as a cancer of unmet need by Cancer Research UK. Consequently, new approaches to therapy are urgently required. Here, we tested the hypothesis that an ATR inhibitor, VX-970, used in...

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Detalhes bibliográficos
Publicado no:Radiother Oncol
Main Authors: Leszczynska, Katarzyna B., Dobrynin, Greg, Leslie, Rhea E., Ient, Jonathan, Boumelha, Adam J., Senra, Joana M., Hawkins, Maria A., Maughan, Tim, Mukherjee, Somnath, Hammond, Ester M.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Scientific Publishers 2016
Assuntos:
Experimental Radiotherapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5154234/
https://ncbi.nlm.nih.gov/pubmed/27839769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.radonc.2016.10.023
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