Characterization of human cytochrome P450 mediated bioactivation of amodiaquine and its major metabolite N‐desethylamodiaquine

Por Zhang, Yongjie, Vermeulen, Nico P. E., Commandeur, Jan N. M.
Publicado no Br J Clin Pharmacol (2016)

Role of residue 87 in substrate selectivity and regioselectivity of drug-metabolizing cytochrome P450 CYP102A1 M11

Por Vottero, Eduardo, Rea, Vanina, Lastdrager, Jeroen, Honing, Maarten, Vermeulen, Nico P. E., Commandeur, Jan N. M.
Publicado em 2011

Enantioselective Substrate Binding in a Monooxygenase Protein Model by Molecular Dynamics and Docking

Por Feenstra, K. Anton, Hofstetter, Karin, Bosch, Rolien, Schmid, Andreas, Commandeur, Jan N. M., Vermeulen, Nico P. E.
Publicado em 2006

Combining substrate dynamics, binding statistics, and energy barriers to rationalize regioselective hydroxylation of octane and lauric acid by CYP102A1 and mutants

Por Feenstra, K. Anton, Starikov, Eugene B., Urlacher, Vlada B., Commandeur, Jan N.M., Vermeulen, Nico P.E.
Publicado em 2007

An on-line post-column detection system for the detection of reactive-oxygen-species-producing compounds and antioxidants in mixtures

Por Kool, Jeroen, Van Liempd, Sebastiaan M., Harmsen, Stefan, Schenk, Tim, Irth, Hubertus, Commandeur, Jan N. M., Vermeulen, Nico P. E.
Publicado em 2007

Application of a cocktail approach to screen cytochrome P450 BM3 libraries for metabolic activity and diversity

Por Reinen, Jelle, Postma, Geert, Tump, Cornelis, Bloemberg, Tom, Engel, Jasper, Vermeulen, Nico P. E., Commandeur, Jan N. M., Honing, Maarten
Publicado no Anal Bioanal Chem (2016)

Linear Interaction Energy Based Prediction of Cytochrome P450 1A2 Binding Affinities with Reliability Estimation

Por Capoferri, Luigi, Verkade-Vreeker, Marlies C. A., Buitenhuis, Danny, Commandeur, Jan N. M., Pastor, Manuel, Vermeulen, Nico P. E., Geerke, Daan P.
Publicado no PLoS One (2015)

Free energies of binding of R- and S-propranolol to wild-type and F483A mutant cytochrome P450 2D6 from molecular dynamics simulations

Por de Graaf, Chris, Oostenbrink, Chris, Keizers, Peter H. J., van Vugt-Lussenburg, Barbara M. A., Commandeur, Jan N. M., Vermeulen, Nico P. E.
Publicado em 2007

Active-site structure, binding and redox activity of the heme–thiolate enzyme CYP2D6 immobilized on coated Ag electrodes: a surface-enhanced resonance Raman scattering study

Por Bonifacio, Alois, Millo, Diego, Keizers, Peter H. J., Boegschoten, Roald, Commandeur, Jan N. M., Vermeulen, Nico P. E., Gooijer, Cees, van der Zwan, Gert
Publicado em 2007

Binding of 7-methoxy-4-(aminomethyl)-coumarin to wild-type and W128F mutant cytochrome P450 2D6 studied by time-resolved fluorescence spectroscopy

Por Stortelder, Aike, Keizers, Peter H. J., Oostenbrink, Chris, De Graaf, Chris, De Kruijf, Petra, Vermeulen, Nico P. E., Gooijer, Cees, Commandeur, Jan N. M., Van Der Zwan, Gert
Publicado em 2006

Altered spin state equilibrium in the T309V mutant of cytochrome P450 2D6: a spectroscopic and computational study

Por Bonifacio, Alois, Groenhof, André R., Keizers, Peter H. J., de Graaf, Chris, Commandeur, Jan N. M., Vermeulen, Nico P. E., Ehlers, Andreas W., Lammertsma, Koop, Gooijer, Cees, van der Zwan, Gert
Publicado em 2007

Selection of antisense oligodeoxynucleotides against glutathione S-transferase Mu.

Por 't Hoen, Peter A C, Out, Ruud, Commandeur, Jan N M, Vermeulen, Nico P E, van Batenburg, F H D, Manoharan, Muthiah, van Berkel, Theo J C, Biessen, Erik A L, Bijsterbosch, Martin K
Publicado em 2002