Binding of 7-methoxy-4-(aminomethyl)-coumarin to wild-type and W128F mutant cytochrome P450 2D6 studied by time-resolved fluorescence spectroscopy

Enzyme structure and dynamics may play a main role in substrate binding and the subsequent steps in the CYP (cytochrome P450) catalytic cycle. In the present study, changes in the structure of human CYP2D6 upon binding of the substrate are studied using steady-state and time-resolved fluorescence me...

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Main Authors: Stortelder, Aike, Keizers, Peter H. J., Oostenbrink, Chris, De Graaf, Chris, De Kruijf, Petra, Vermeulen, Nico P. E., Gooijer, Cees, Commandeur, Jan N. M., Van Der Zwan, Gert
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2006
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1360716/
https://ncbi.nlm.nih.gov/pubmed/16190863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20051169
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