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Characterization of human cytochrome P450 mediated bioactivation of amodiaquine and its major metabolite N‐desethylamodiaquine
AIMS: Oxidative bioactivation of amodiaquine (AQ) by cytochrome P450s to a reactive quinoneimine is considered as an important mechanism underlying its idiosyncratic hepatotoxicity. However, because internal exposure to its major metabolite N‐desethylamodiaquine (DEAQ) is up to 240‐fold higher than...
Na minha lista:
| Foilsithe in: | Br J Clin Pharmacol |
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| Main Authors: | , , |
| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
John Wiley and Sons Inc.
2016
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5306493/ https://ncbi.nlm.nih.gov/pubmed/27718269 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13148 |
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