Pharmacokinetic profile of amodiaquine and its active metabolite desethylamodiaquine in Ghanaian patients with uncomplicated falciparum malaria

BACKGROUND: Accurate measurement of anti-malarial drug concentrations in therapeutic efficacy studies is essential to distinguish between inadequate drug exposure and anti-malarial drug resistance, and to inform optimal anti-malarial dosing in key target population groups. METHODS: A sensitive and s...

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Vydáno v:Malar J
Hlavní autoři: Anyorigiya, Thomas A., Castel, Sandra, Mauff, Katya, Atuguba, Frank, Ogutu, Bernhards, Oduro, Abraham, Dosoo, David, Asante, Kwaku-Poku, Owusu-Agyei, Seth, Dodoo, Alexander, Hodgson, Abraham, Binka, Fred, Workman, Lesley J., Allen, Elizabeth N., Denti, Paolo, Wiesner, Lubbe, Barnes, Karen I.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2021
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7788723/
https://ncbi.nlm.nih.gov/pubmed/33407454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12936-020-03553-6
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