Cardiovascular concentration–effect relationships of amodiaquine and its metabolite desethylamodiaquine: Clinical and preclinical studies

AIMS: Amodiaquine is a 4‐aminoquinoline used extensively for the treatment and prevention of malaria. Orally administered amodiaquine is largely converted to the active metabolite desethylamodiaquine. Amodiaquine can cause bradycardia, hypotension, and electrocardiograph QT interval prolongation, bu...

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Bibliografiske detaljer
Udgivet i:Br J Clin Pharmacol
Main Authors: Chan, Xin Hui S., Chotsiri, Palang, Capel, Rebecca A., Pike, James, Hanboonkunupakarn, Borimas, Lee, Sue J., Hanafiah, Maryam, Win, Yan Naung, Cremer, Maegan A., Kiechel, Jean‐René, Ogutu, Bernhards, Taylor, Walter R. J., Burton, Rebecca‐Ann B., Tarning, Joel, White, Nicholas J.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2022
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Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7614325/
https://ncbi.nlm.nih.gov/pubmed/36256474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.15569
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