Altered spin state equilibrium in the T309V mutant of cytochrome P450 2D6: a spectroscopic and computational study

Cytochrome P450 2D6 (CYP2D6) is one of the most important cytochromes P450 in humans. Resonance Raman data from the T309V mutant of CYP2D6 show that the substitution of the conserved I-helix threonine situated in the enzyme’s active site perturbs the heme spin equilibrium in favor of the six-coordin...

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Detalhes bibliográficos
Main Authors: Bonifacio, Alois, Groenhof, André R., Keizers, Peter H. J., de Graaf, Chris, Commandeur, Jan N. M., Vermeulen, Nico P. E., Ehlers, Andreas W., Lammertsma, Koop, Gooijer, Cees, van der Zwan, Gert
Formato: Artigo
Idioma:Inglês
Publicado em: Springer-Verlag 2007
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1915625/
https://ncbi.nlm.nih.gov/pubmed/17318599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00775-007-0210-5
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