Reversed-phase liquid chromatography coupled on-line to estrogen receptor bioaffinity detection based on fluorescence polarization

Por Reinen, Jelle, Kool, Jeroen, Vermeulen, Nico P. E.
Publicado em 2008

Involvement of the Pleiotropic Drug Resistance Response, Protein Kinase C Signaling, and Altered Zinc Homeostasis in Resistance of Saccharomyces cerevisiae to Diclofenac

Por van Leeuwen, Jolanda S., Vermeulen, Nico P. E., Vos, J. Chris
Publicado em 2011

Characterization of human cytochrome P450 mediated bioactivation of amodiaquine and its major metabolite N‐desethylamodiaquine

Por Zhang, Yongjie, Vermeulen, Nico P. E., Commandeur, Jan N. M.
Publicado no Br J Clin Pharmacol (2016)

Binding free energy predictions of farnesoid X receptor (FXR) agonists using a linear interaction energy (LIE) approach with reliability estimation: application to the D3R Grand Ch...

Por Rifai, Eko Aditya, van Dijk, Marc, Vermeulen, Nico P. E., Geerke, Daan P.
Publicado no J Comput Aided Mol Des (2017)

Role of residue 87 in substrate selectivity and regioselectivity of drug-metabolizing cytochrome P450 CYP102A1 M11

Por Vottero, Eduardo, Rea, Vanina, Lastdrager, Jeroen, Honing, Maarten, Vermeulen, Nico P. E., Commandeur, Jan N. M.
Publicado em 2011

Enantioselective Substrate Binding in a Monooxygenase Protein Model by Molecular Dynamics and Docking

Por Feenstra, K. Anton, Hofstetter, Karin, Bosch, Rolien, Schmid, Andreas, Commandeur, Jan N. M., Vermeulen, Nico P. E.
Publicado em 2006

Combining substrate dynamics, binding statistics, and energy barriers to rationalize regioselective hydroxylation of octane and lauric acid by CYP102A1 and mutants

Por Feenstra, K. Anton, Starikov, Eugene B., Urlacher, Vlada B., Commandeur, Jan N.M., Vermeulen, Nico P.E.
Publicado em 2007

Improving the iterative Linear Interaction Energy approach using automated recognition of configurational transitions

Por Vosmeer, C. Ruben, Kooi, Derk P., Capoferri, Luigi, Terpstra, Margreet M., Vermeulen, Nico P. E., Geerke, Daan. P.
Publicado no J Mol Model (2016)

Towards Automated Binding Affinity Prediction Using an Iterative Linear Interaction Energy Approach

Por Vosmeer, C. Ruben, Pool, René, van Stee, Mariël F., Perić-Hassler, Lovorka, Vermeulen, Nico P. E., Geerke, Daan P.
Publicado em 2014

Comprehensive and Automated Linear Interaction Energy Based Binding-Affinity Prediction for Multifarious Cytochrome P450 Aromatase Inhibitors

Por van Dijk, Marc, ter Laak, Antonius M., Wichard, Jörg D., Capoferri, Luigi, Vermeulen, Nico P. E., Geerke, Daan P.
Publicado no J Chem Inf Model (2017)

An on-line post-column detection system for the detection of reactive-oxygen-species-producing compounds and antioxidants in mixtures

Por Kool, Jeroen, Van Liempd, Sebastiaan M., Harmsen, Stefan, Schenk, Tim, Irth, Hubertus, Commandeur, Jan N. M., Vermeulen, Nico P. E.
Publicado em 2007

Application of a cocktail approach to screen cytochrome P450 BM3 libraries for metabolic activity and diversity

Por Reinen, Jelle, Postma, Geert, Tump, Cornelis, Bloemberg, Tom, Engel, Jasper, Vermeulen, Nico P. E., Commandeur, Jan N. M., Honing, Maarten
Publicado no Anal Bioanal Chem (2016)

Linear Interaction Energy Based Prediction of Cytochrome P450 1A2 Binding Affinities with Reliability Estimation

Por Capoferri, Luigi, Verkade-Vreeker, Marlies C. A., Buitenhuis, Danny, Commandeur, Jan N. M., Pastor, Manuel, Vermeulen, Nico P. E., Geerke, Daan P.
Publicado no PLoS One (2015)

Free energies of binding of R- and S-propranolol to wild-type and F483A mutant cytochrome P450 2D6 from molecular dynamics simulations

Por de Graaf, Chris, Oostenbrink, Chris, Keizers, Peter H. J., van Vugt-Lussenburg, Barbara M. A., Commandeur, Jan N. M., Vermeulen, Nico P. E.
Publicado em 2007

The effect of acetaminophen on ubiquitin homeostasis in Saccharomyces cerevisiae

Por Huseinovic, Angelina, van Leeuwen, Jolanda S., van Welsem, Tibor, Stulemeijer, Iris, van Leeuwen, Fred, Vermeulen, Nico P. E., Kooter, Jan M., Vos, J. Chris
Publicado no PLoS One (2017)

eTOX ALLIES: an automated pipeLine for linear interaction energy-based simulations

Por Capoferri, Luigi, van Dijk, Marc, Rustenburg, Ariën S., Wassenaar, Tsjerk A., Kooi, Derk P., Rifai, Eko A., Vermeulen, Nico P. E., Geerke, Daan P.
Publicado no J Cheminform (2017)

Active-site structure, binding and redox activity of the heme–thiolate enzyme CYP2D6 immobilized on coated Ag electrodes: a surface-enhanced resonance Raman scattering study

Por Bonifacio, Alois, Millo, Diego, Keizers, Peter H. J., Boegschoten, Roald, Commandeur, Jan N. M., Vermeulen, Nico P. E., Gooijer, Cees, van der Zwan, Gert
Publicado em 2007

Evidence-based selection of training compounds for use in the mechanism-based integrated prediction of drug-induced liver injury in man

Por Dragovic, Sanja, Vermeulen, Nico P. E., Gerets, Helga H., Hewitt, Philip G., Ingelman‐Sundberg, Magnus, Park, B. Kevin, Juhila, Satu, Snoeys, Jan, Weaver, Richard J.
Publicado no Arch Toxicol (2016)

Binding of 7-methoxy-4-(aminomethyl)-coumarin to wild-type and W128F mutant cytochrome P450 2D6 studied by time-resolved fluorescence spectroscopy

Por Stortelder, Aike, Keizers, Peter H. J., Oostenbrink, Chris, De Graaf, Chris, De Kruijf, Petra, Vermeulen, Nico P. E., Gooijer, Cees, Commandeur, Jan N. M., Van Der Zwan, Gert
Publicado em 2006

Glutathione S-Transferase P1 Protects Against Amodiaquine Quinoneimines-Induced Cytotoxicity but Does Not Prevent Activation of Endoplasmic Reticulum Stress in HepG2 Cells

Por Zhang, Yongjie, den Braver-Sewradj, Shalenie P., den Braver, Michiel W., Hiemstra, Steven, Vermeulen, Nico P. E., van de Water, Bob, Commandeur, Jan N. M., Vos, J. C.
Publicado no Front Pharmacol (2018)