Pathogenic mechanisms and therapeutic strategies in spinobulbar muscular atrophy

Por Chua, Jason P., Lieberman, Andrew P.
Publicado em 2013

Bisphenol A is released from polycarbonate drinking bottles and mimics the neurotoxic actions of estrogen in developing cerebellar neurons

Por Le, Hoa H., Carlson, Emily M., Chua, Jason P., Belcher, Scott M.
Publicado em 2007

Transcriptional activation of TFEB/ZKSCAN3 target genes underlies enhanced autophagy in spinobulbar muscular atrophy

Por Chua, Jason P., Reddy, Satya L., Merry, Diane E., Adachi, Hiroaki, Katsuno, Masahisa, Sobue, Gen, Robins, Diane M., Lieberman, Andrew P.
Publicado em 2014

Rescue of metabolic alterations in AR113Q skeletal muscle by peripheral androgen receptor gene silencing

Por Giorgetti, Elisa, Yu, Zhigang, Chua, Jason P., Shimamura, Ryosuke, Zhao, Lili, Zhu, Fan, Venneti, Sriram, Pennuto, Maria, Guan, Yuanfang, Hung, Gene, Lieberman, Andrew P.
Publicado no Cell Rep (2016)

Antiandrogen Flutamide Protects Male Mice From Androgen-Dependent Toxicity in Three Models of Spinal Bulbar Muscular Atrophy

Por Renier, Kayla J., Troxell-Smith, Sandra M., Johansen, Jamie A., Katsuno, Masahisa, Adachi, Hiroaki, Sobue, Gen, Chua, Jason P., Sun Kim, Hong, Lieberman, Andrew P., Breedlove, S. Marc, Jordan, Cynthia L.
Publicado em 2014

Disrupting SUMOylation enhances transcriptional function and ameliorates polyglutamine androgen receptor–mediated disease

Por Chua, Jason P., Reddy, Satya L., Yu, Zhigang, Giorgetti, Elisa, Montie, Heather L., Mukherjee, Sarmistha, Higgins, Jake, McEachin, Richard C., Robins, Diane M., Merry, Diane E., Iñiguez-Lluhí, Jorge A., Lieberman, Andrew P.
Publicado no J Clin Invest (2015)

Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation

Por Wang, Adrienne M., Miyata, Yoshinari, Klinedinst, Susan, Peng, Hwei-Ming, Chua, Jason P., Komiyama, Tomoko, Li, Xiaokai, Morishima, Yoshihiro, Merry, Diane E., Pratt, William B., Osawa, Yoichi, Collins, Catherine A., Gestwicki, Jason E., Lieberman, Andrew P.
Publicado em 2012