Disrupting SUMOylation enhances transcriptional function and ameliorates polyglutamine androgen receptor–mediated disease

Expansion of the polyglutamine (polyQ) tract within the androgen receptor (AR) causes neuromuscular degeneration in individuals with spinobulbar muscular atrophy (SBMA). PolyQ AR has diminished transcriptional function and exhibits ligand-dependent proteotoxicity, features that have both been implic...

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Pubblicato in:J Clin Invest
Autori principali: Chua, Jason P., Reddy, Satya L., Yu, Zhigang, Giorgetti, Elisa, Montie, Heather L., Mukherjee, Sarmistha, Higgins, Jake, McEachin, Richard C., Robins, Diane M., Merry, Diane E., Iñiguez-Lluhí, Jorge A., Lieberman, Andrew P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4319414/
https://ncbi.nlm.nih.gov/pubmed/25607844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI73214
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