Disrupting SUMOylation enhances transcriptional function and ameliorates polyglutamine androgen receptor–mediated disease

Expansion of the polyglutamine (polyQ) tract within the androgen receptor (AR) causes neuromuscular degeneration in individuals with spinobulbar muscular atrophy (SBMA). PolyQ AR has diminished transcriptional function and exhibits ligand-dependent proteotoxicity, features that have both been implic...

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Vydáno v:J Clin Invest
Hlavní autoři: Chua, Jason P., Reddy, Satya L., Yu, Zhigang, Giorgetti, Elisa, Montie, Heather L., Mukherjee, Sarmistha, Higgins, Jake, McEachin, Richard C., Robins, Diane M., Merry, Diane E., Iñiguez-Lluhí, Jorge A., Lieberman, Andrew P.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2015
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4319414/
https://ncbi.nlm.nih.gov/pubmed/25607844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI73214
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