Disrupting SUMOylation enhances transcriptional function and ameliorates polyglutamine androgen receptor–mediated disease

Expansion of the polyglutamine (polyQ) tract within the androgen receptor (AR) causes neuromuscular degeneration in individuals with spinobulbar muscular atrophy (SBMA). PolyQ AR has diminished transcriptional function and exhibits ligand-dependent proteotoxicity, features that have both been implic...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Chua, Jason P., Reddy, Satya L., Yu, Zhigang, Giorgetti, Elisa, Montie, Heather L., Mukherjee, Sarmistha, Higgins, Jake, McEachin, Richard C., Robins, Diane M., Merry, Diane E., Iñiguez-Lluhí, Jorge A., Lieberman, Andrew P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2015
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4319414/
https://ncbi.nlm.nih.gov/pubmed/25607844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI73214
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