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Polyglutamine androgen receptor-mediated neuromuscular disease
An expanded polyglutamine (polyQ) tract at the amino-terminus of the androgen receptor (AR) confers toxic properties responsible for neuronal and non-neuronal degeneration in spinal and bulbar muscular atrophy (SBMA), one of nine polyQ expansion diseases. Both lower motor neurons and peripheral tiss...
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| Pubblicato in: | Cell Mol Life Sci |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Springer International Publishing
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5045769/ https://ncbi.nlm.nih.gov/pubmed/27188284 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-016-2275-1 |
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