Small Ubiquitin-like Modifier (SUMO) Modification of the Androgen Receptor Attenuates Polyglutamine-mediated Aggregation

The neurodegenerative disorder spinal and bulbar muscular atrophy or Kennedy disease is caused by a CAG trinucleotide repeat expansion within the androgen receptor (AR) gene. The resulting expanded polyglutamine tract in the N-terminal region of the receptor renders AR prone to ligand-dependent misf...

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Detalhes bibliográficos
Main Authors: Mukherjee, Sarmistha, Thomas, Monzy, Dadgar, Nahid, Lieberman, Andrew P., Iñiguez-Lluhí, Jorge A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Protein Synthesis, Post-Translational Modification, and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2755854/
https://ncbi.nlm.nih.gov/pubmed/19497852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.011494
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