Modification of Drosophila p53 by SUMO Modulates Its Transactivation and Pro-apoptotic Functions

Conjugation to SUMO is a reversible post-translational modification that regulates several transcription factors involved in cell proliferation, differentiation, and disease. The p53 tumor suppressor can be modified by SUMO-1 in mammalian cells, but the functional consequences of this modification a...

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Autores principales: Mauri, Federico, McNamee, Laura M., Lunardi, Andrea, Chiacchiera, Fulvio, Del Sal, Giannino, Brodsky, Michael H., Collavin, Licio
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2008
Materias:
Protein Synthesis, Post-Translational Modification, and Degradation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3258953/
https://ncbi.nlm.nih.gov/pubmed/18492669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M710186200
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