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Ref-1 regulates the transactivation and pro-apoptotic functions of p53 in vivo.
Ref-1 is a multifunctional protein that stimulates DNA binding by a number of transcription factors and serves as the abasic (A/P) endonuclease in base excision repair. Ref-1 was discovered to be a potent activator of p53 DNA binding in vitro. To address the physiological significance of the effects...
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| Main Authors: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
1999
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1171629/ https://ncbi.nlm.nih.gov/pubmed/10523305 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.20.5609 |
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