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Overexpression of wild-type androgen receptor in muscle recapitulates polyglutamine disease
We created transgenic mice that overexpress WT androgen receptor (AR) exclusively in their skeletal muscle fibers. Unexpectedly, these mice display androgen-dependent muscle weakness and early death, show changes in muscle morphology and gene expression consistent with neurogenic atrophy, and exhibi...
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| 主要な著者: | , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2007
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2084330/ https://ncbi.nlm.nih.gov/pubmed/17984063 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0705501104 |
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