Prenatal Flutamide Enhances Survival in a Myogenic Mouse Model of Spinal Bulbar Muscular Atrophy

BACKGROUND: Spinal bulbar muscular atrophy (SBMA) is caused by a CAG repeat expansion mutation in the androgen receptor (AR) gene, and mutant AR is presumed to act in motoneurons to cause SBMA. However, we found that mice overexpressing wild-type (wt) AR solely in skeletal muscle fibers display the...

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Bibliographic Details
Main Authors: Johansen, Jamie A., Troxell-Smith, Sandra M., Yu, Zhigang, Mo, Kaiguo, Monks, D. Ashley, Lieberman, Andrew P., Breedlove, S. Marc, Jordan, Cynthia L.
Format: Artigo
Language:Inglês
Published: S. Karger AG 2010
Subjects:
Modeling Neurodegenerative Diseases in vivo
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3030474/
https://ncbi.nlm.nih.gov/pubmed/20689246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000313682
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