Antiandrogen Flutamide Protects Male Mice From Androgen-Dependent Toxicity in Three Models of Spinal Bulbar Muscular Atrophy

Spinal and bulbar muscular atrophy (SBMA) is a late-onset, progressive neurodegenerative disease linked to a polyglutamine (polyQ) expansion in the androgen receptor (AR). Men affected by SBMA show marked muscle weakness and atrophy, typically emerging midlife. Given the androgen-dependent nature of...

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Autori principali: Renier, Kayla J., Troxell-Smith, Sandra M., Johansen, Jamie A., Katsuno, Masahisa, Adachi, Hiroaki, Sobue, Gen, Chua, Jason P., Sun Kim, Hong, Lieberman, Andrew P., Breedlove, S. Marc, Jordan, Cynthia L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Endocrine Society 2014
Soggetti:
Neuroendocrinology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4060177/
https://ncbi.nlm.nih.gov/pubmed/24742193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2013-1756
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