Contractile dysfunction in muscle may underlie androgen-dependent motor dysfunction in spinal bulbar muscular atrophy

Spinal and bulbar muscular atrophy (SBMA) is characterized by progressive muscle weakness linked to a polyglutamine expansion in the androgen receptor (AR). Current evidence indicates that mutant AR causes SBMA by acting in muscle to perturb its function. However, information about how muscle functi...

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Veröffentlicht in:J Appl Physiol (1985)
Hauptverfasser: Oki, Kentaro, Halievski, Katherine, Vicente, Laura, Xu, Youfen, Zeolla, Donald, Poort, Jessica, Katsuno, Masahisa, Adachi, Hiroaki, Sobue, Gen, Wiseman, Robert W., Breedlove, S. Marc, Jordan, Cynthia L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4385878/
https://ncbi.nlm.nih.gov/pubmed/25663674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/japplphysiol.00886.2014
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