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Pre-clinical symptoms of SBMA may not be androgen-dependent: implications from two SBMA mouse models
A distinguishing aspect of spinal and bulbar muscular atrophy (SBMA) is its androgen-dependence, possibly explaining why only males are clinically affected. This disease, which impairs neuromuscular function, is linked to a polyglutamine expansion mutation in the androgen receptor (AR). In mouse mod...
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| Publicado no: | Hum Mol Genet |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6030880/ https://ncbi.nlm.nih.gov/pubmed/29897452 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddy142 |
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