Pre-clinical symptoms of SBMA may not be androgen-dependent: implications from two SBMA mouse models

A distinguishing aspect of spinal and bulbar muscular atrophy (SBMA) is its androgen-dependence, possibly explaining why only males are clinically affected. This disease, which impairs neuromuscular function, is linked to a polyglutamine expansion mutation in the androgen receptor (AR). In mouse mod...

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Bibliographic Details
Published in:Hum Mol Genet
Main Authors: Xu, Youfen, Halievski, Katherine, Katsuno, Masahisa, Adachi, Hiroaki, Sobue, Gen, Breedlove, S Marc, Jordan, Cynthia L
Format: Artigo
Language:Inglês
Published: Oxford University Press 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6030880/
https://ncbi.nlm.nih.gov/pubmed/29897452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddy142
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