Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation

We sought novel strategies to reduce levels of the polyglutamine androgen receptor (polyQ AR) and achieve therapeutic benefits in models of spinobulbar muscular atrophy (SBMA), a protein aggregation neurodegenerative disorder. Proteostasis of the polyQ AR is controlled by the Hsp90/Hsp70-based chape...

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Autors principals: Wang, Adrienne M., Miyata, Yoshinari, Klinedinst, Susan, Peng, Hwei-Ming, Chua, Jason P., Komiyama, Tomoko, Li, Xiaokai, Morishima, Yoshihiro, Merry, Diane E., Pratt, William B., Osawa, Yoichi, Collins, Catherine A., Gestwicki, Jason E., Lieberman, Andrew P.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3552084/
https://ncbi.nlm.nih.gov/pubmed/23222885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1140
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