Early Engineering Approaches to Improve Peptide Developability and Manufacturability

von Furman, Jennifer L., Chiu, Mark, Hunter, Michael J.
Veröffentlicht in AAPS J (2014)

Fc Engineering Approaches to Enhance the Agonism and Effector Functions of an Anti-OX40 Antibody

von Zhang, Di, Goldberg, Monica V., Chiu, Mark L.
Veröffentlicht in J Biol Chem (2016)

Raman spectroscopy characterization of antibody phases in serum

von Baker, Audrey E, Mantz, Amber R, Chiu, Mark L
Veröffentlicht in MAbs (2014)

FcγRII-binding Centyrins mediate agonism and antibody-dependent cellular phagocytosis when fused to an anti-OX40 antibody

von Zhang, Di, Whitaker, Brian, Derebe, Mehabaw G., Chiu, Mark L.
Veröffentlicht in MAbs (2018)

Antibody Structure and Function: The Basis for Engineering Therapeutics

von Chiu, Mark L., Goulet, Dennis R., Teplyakov, Alexey, Gilliland, Gary L.
Veröffentlicht in Antibodies (Basel) (2019)

Effect of Sequence and Stereochemistry Reversal on p53 Peptide Mimicry

von Atzori, Alessio, Baker, Audrey E., Chiu, Mark, Bryce, Richard A., Bonnet, Pascal
Veröffentlicht 2013

Diffusion of Soluble Aggregates of THIOMABs and Bispecific Antibodies in Serum

von Goulet, Dennis R., Zwolak, Adam, Chiu, Mark L., Nath, Abhinav, Atkins, William M.
Veröffentlicht in Biochemistry (2017)

Cross-arm binding efficiency of an EGFR x c-Met bispecific antibody

von Zheng, Songmao, Moores, Sheri, Jarantow, Stephen, Pardinas, Jose, Chiu, Mark, Zhou, Honghui, Wang, Weirong
Veröffentlicht in MAbs (2016)

Influence of the bispecific antibody IgG subclass on T cell redirection

von Kapelski, Stephanie, Cleiren, Erna, Attar, Ricardo M., Philippar, Ulrike, Häsler, Julien, Chiu, Mark L.
Veröffentlicht in MAbs (2019)

Design and characterization of novel dual Fc antibody with enhanced avidity for Fc receptors

von Goulet, Dennis R., Zwolak, Adam, Williams, James A., Chiu, Mark L., Atkins, William M.
Veröffentlicht in Proteins (2019)

Characterization of a Novel Bispecific Antibody That Activates T Cells In Vitro and Slows Tumor Growth In Vivo

von Chornoguz, Olesya, Leettola, Catherine N., Leander, Karen, Brosnan, Kerry, Emmell, Eva, Chiu, Mark L., Santulli-Marotto, Sandra
Veröffentlicht in Monoclon Antib Immunodiagn Immunother (2019)

Toward a Combinatorial Approach for the Prediction of IgG Half-Life and Clearance

von Goulet, Dennis R., Watson, Michael J., Tam, Susan H., Zwolak, Adam, Chiu, Mark L., Atkins, William M., Nath, Abhinav
Veröffentlicht in Drug Metab Dispos (2018)

Functional optimization of agonistic antibodies to OX40 receptor with novel Fc mutations to promote antibody multimerization

von Zhang, Di, Armstrong, Anthony A., Tam, Susan H., McCarthy, Stephen G., Luo, Jinquan, Gilliland, Gary L., Chiu, Mark L.
Veröffentlicht in MAbs (2017)

Fc-mediated activity of EGFR x c-Met bispecific antibody JNJ-61186372 enhanced killing of lung cancer cells

von Grugan, Katharine D., Dorn, Keri, Jarantow, Stephen W., Bushey, Barbara S., Pardinas, Jose R., Laquerre, Sylvie, Moores, Sheri L., Chiu, Mark L.
Veröffentlicht in MAbs (2016)

Kinetic mechanism of controlled Fab-arm exchange for the formation of bispecific immunoglobulin G1 antibodies

von Goulet, Dennis R., Orcutt, Steven J., Zwolak, Adam, Rispens, Theo, Labrijn, Aran F., de Jong, Rob N., Atkins, William M., Chiu, Mark L.
Veröffentlicht in J Biol Chem (2018)

Impact of Cell-surface Antigen Expression on Target Engagement and Function of an Epidermal Growth Factor Receptor × c-MET Bispecific Antibody

von Jarantow, Stephen W., Bushey, Barbara S., Pardinas, Jose R., Boakye, Ken, Lacy, Eilyn R., Sanders, Renouard, Sepulveda, Manuel A., Moores, Sheri L., Chiu, Mark L.
Veröffentlicht in J Biol Chem (2015)

Rapid Purification of Human Bispecific Antibodies via Selective Modulation of Protein A Binding

von Zwolak, Adam, Leettola, Catherine N., Tam, Susan H., Goulet, Dennis R., Derebe, Mehabaw G., Pardinas, Jose R., Zheng, Songmao, Decker, Rose, Emmell, Eva, Chiu, Mark L.
Veröffentlicht in Sci Rep (2017)

Modulation of protein A binding allows single-step purification of mouse bispecific antibodies that retain FcRn binding

von Zwolak, Adam, Armstrong, Anthony A., Tam, Susan H., Pardinas, Jose R., Goulet, Dennis R., Zheng, Songmao, Brosnan, Kerry, Emmell, Eva, Luo, Jeffrey, Gilliland, Gary L., Chiu, Mark L.
Veröffentlicht in MAbs (2017)

Efficient Generation of Bispecific Murine Antibodies for Pre-Clinical Investigations in Syngeneic Rodent Models

von Labrijn, Aran F., Meesters, Joyce I., Bunce, Matthew, Armstrong, Anthony A., Somani, Sandeep, Nesspor, Tom C., Chiu, Mark L., Altintaş, Işil, Verploegen, Sandra, Schuurman, Janine, Parren, Paul W. H. I.
Veröffentlicht in Sci Rep (2017)

Discovery of amivantamab (JNJ-61186372), a bispecific antibody targeting EGFR and MET

von Neijssen, Joost, Cardoso, Rosa M.F., Chevalier, Kristen M., Wiegman, Luus, Valerius, Thomas, Anderson, G. Mark, Moores, Sheri L., Schuurman, Janine, Parren, Paul W.H.I., Strohl, William R., Chiu, Mark L.
Veröffentlicht in J Biol Chem (2021)